Decreased circulating levels of betatrophin in Chinese women with polycystic ovary syndrome
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چکیده
The release and regulation of betatrophin in women with polycystic ovary syndrome (PCOS) haven’t been well known. The study was to investigate circulating betatrophin levels in women with PCOS and the correlations with insulin resistance and biochemical parameters in two cohorts. In cohort 1, 90 women with PCOS and 85 age-matched healthy women were recruited in a cross-sectional study. Serum concentrations of betatrophin were measured. Serum betatrophin levels were significantly lower in PCOS patients than that in healthy control subjects (0.43 ± 0.15 ng/mL vs 1.19 ± 0.57 ng/mL, P<0.001). Serum betatrophin negatively correlated with fasting plasma glucose (FPG), 2 h postprandial plasma glucose (2hPG), fasting insulin (FINS), triglycerides (TG), homeostasis model assessment of insulin resistance (HOMA-IR), total testosterone (T), and high-sensitivity C-reaction protein (hs-CRP), even after controlling for age and body mass index (BMI) in PCOS participants (all P<0.05). Moreover, stepwise multiple regression analysis showed that HOMA-IR was independently related to betatrophin in PCOS subjects (P<0.05). In cohort 2, 72 PCOS patients were observed longitudinally after 3 months of rosiglitazone + metformin treatment. After treatment, PCOS patients showed higher betatrophin concentrations than the baseline (0.85 ± 0.51 ng/ml vs 0.43 ± 0.18 ng/ml, P<0.001). Circulating betatrophin levels were decreased in patients with PCOS, and associated with indexes of insulin resistance and/or other metabolic abnormalities of PCOS (e.g., hyperandrogenemia).
منابع مشابه
Serum betatrophin levels are increased and associated with insulin resistance in patients with polycystic ovary syndrome
Objective Betatrophin is a newly identified circulating protein that is significantly associated with type 2 diabetes mellitus (T2DM), adiposity, and metabolic syndrome. The aim of this study was to investigate whether betatrophin levels and polycystic ovary syndrome (PCOS) were associated. Methods Circulating betatrophin levels were measured in 162 patients with PCOS and 156 matched control fe...
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INTRODUCTION Data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance (IR). The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of IR and insulin secretion in women with PCOS, compared to the control group. METHODS The study group comprised 43 women with...
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تاریخ انتشار 2017